Making reliable estimates of the amounts of chemicals deposited on the skin and clothing in the workplace is essential in evaluating any health risks. It also helps in assessing the effectiveness of protective equipment. There is a lack of detailed […]
Measurement of human exposure at work forms the cornerstone of risk management strategies. With the advent of powerful computer databases these measurements have been collected in several parts of Europe, by industry, government agencies and others such as universities and […]
Cefic identified a need for an inventory of European research on human workplace exposure to chemicals. Access to this information is needed for setting safe occupational exposure limits and to help quantify economic and health implications of exposures. A database […]
The widespread use and acceptance of PBPK modelling has been advocated for many years, as this technique offers a more scientific and quantitative approach to chemical risk assessment, as well as offering the opportunity of a marked reduction in the […]
The aim of this project is to investigate how the variability and uncertainty of occupational inhalation exposure information may be better incorporated into the European regulatory risk assessment process. In this proposal, we have chosen to focus specifically on inhalation […]
This project will evaluate the estimates used today by several organisations (e.g. U.S.-EPA, WHO, EU) to assess the human health risks of chemical exposure, which result in the derivation of human limit values such as acceptable daily intake, reference doses […]
Many adverse health effects of chemical exposure occur after repeated contact over long periods. In assessing the risks of such chronic effects in the workplace, "reasonable worst case" estimates of exposure during a shift or working day are often used. […]
The toxicological data profiles of many of the more than 100,000 substances included in the EINECS are incomplete. Scientific tools are needed to minimize test requirements and to prioritise research needs. Here consideration of Structure Activity Relationships (SAR) could be […]
The main objective of this project is to use dendritic-like cells derived from a human cell line to develop a robust in vitro system to distinguish between respiratory vs contact sensitising chemicals. Whilst the use of cell lines will help […]
The main objective of this project is the development of an approach/strategy that can be used to identify chemical allergens and if possible to discern respiratory from contact sensitizers. In order to accomplish this, the proposed study aims to identify […]
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