Acceptance of technology
AIMT1-PG: Evaluation of Signal Transduction Pathways in Model Organisms as Critical Mediators of Developmental Toxicity
The overall objective of the project is to determine whether model organisms with genetically sensitized signal transduction pathways can be used as predictors of mammalian developmental toxicity. Specific objectives: - Evaluate the effect of model developmental toxicants on the morphological […]
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S1-WAG: Safety Perceptions of New Technologies (SPOT) – making social and natural sciences meet
Many new technologies' introductions have been hindered by societal negativity regarding their development, application and commercialisation. Whilst considerable research activity has been directed towards understanding the underlying determinants of societal acceptance emerging technologies, this has been done on a case […]
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N1-FRAU: Tiered Approach to Testing and Assessment of Nanomaterial Safety to Human Health
The objectives of this project are: - to test the suitability of existing OECD testing guidelines for nanoscaled amorphous silicon dioxide (NASD) and ZnO; - to subject these test materials to OECD guideline testing; - to supplement these guidelines with […]
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N2-YORK: Detection, Fate and Uptake of Engineered Nanoparticles in Aquatic Systems
Nanotechnology is a new and fast emerging field that involves manufacture of materials that are less than 100 nm in size in one dimension. Due to their extremely small size, engineered nanoparticles (ENPs) exhibit properties that are vastly different from […]
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N3-TNO: Testing and Assessment of Reproductive Toxicity of Nanomaterials
Nanomaterials form an important new class of technological materials that have numerous novel and useful properties. The expected growth in production and use of such materials increases the likelihood of human and environmental exposure. Evidence exists that children may be […]
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ECO14bis-UNT: Alternative methodology for standard laboratory fish bioconcentration tests
The overall goal of this project is to recommend a scientifically sound and defensible minimalized experimental design for fish bioconcentration measurement. This experimental design will meet the "spirit" of the OECD 305 protocol producing key regulatory data, but ideally will […]
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ECO15/14-15.2-USTO: Rapid estimation of TMF using laboratory, field and computer modelling methods in aquatic organisms
Chemical bioaccumulation is an interesting scientific phenomenon and an important regulatory consideration. The production and use of chemicals that are assessed as having a high potential to accumulate can be restricted in many jurisdictions. At the same time, recent scientific […]
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ECO16 – IRAS: Generate a validated CBR database and validate a CBR chronic toxicity range for narcotics
The general objective of the research project is to generate greater confidence and acceptance for the application of CBBs in the scientific community and in regulatory contexts. A key element of this research will be to compare model predictions that provide mechanistic […]
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ECO3A.2-USTO: Creation, Evaluation and Application of an Integrated Environmental Fate and Human Food Chain Bioaccumulation Model for Polar and Non-polar Organic Substances (IMPS)
The goals of the project are: To create a mechanistically based, non-steady state, chemical fate and bioaccumulation model to predict wildlife and human exposure to organic chemicals. To further develop this model to make it applicable to polar chemicals that […]
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A2.2-UNJM: Determination of the Optimal Physico-Chemical Parameters to Use in a QSAR Approach to Predict Skin Permeation Rate
Many toxic chemicals can enter the body via the skin. Measuring a chemical's ability to cross the skin is difficult, time-consuming and costly. One solution is to develop models relating skin permeability to chemical structure - known as a quantitative […]
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