When aquatic organisms are exposed to chemicals in the environment, some of these chemicals maybe universally metabolised, whilst others are either metabolised by specific species/taxa or are non-metabolisable and therefore may bioaccumulate. The objective of this work was to develop […]
Many chemicals are used daily in the home, in diverse end-uses such as cleaning, renovating and caring for houseplants. Product labels give advice on safe use, but there is scope to improve understanding of potential risks. One approach is to […]
The main objective of this project is to use dendritic-like cells derived from a human cell line to develop a robust in vitro system to distinguish between respiratory vs contact sensitising chemicals. Whilst the use of cell lines will help […]
The main objective of this project is the development of an approach/strategy that can be used to identify chemical allergens and if possible to discern respiratory from contact sensitizers. In order to accomplish this, the proposed study aims to identify […]
This project aimed to improve hazard identification of respiratory chemical allergens, as is presently being done by measuring proliferation and cytokine production in local lymph nodes and IgE in serum upon dermal application of the chemical in question. To this […]
Allergic hypersensitivity of the respiratory tract is an important occupational health problem. A major constraint in the development of appropriate methods for the prospective identification of chemical respiratory allergens is the continuing uncertainty regarding the immunobiological mechanisms of this disease […]
A range of low molecular weight chemicals can cause adverse reactions in the airways such as allergic asthma, including occupational asthma. Allergies involve a generally symptom-free induction phase where sensitisation is induced, and an elicitation (challenge) phase, where inhalation of […]
Some chemicals can induce allergies, including allergy of the lungs and other parts of the respiratory tract. (Examples include acid anhydrides, certain diisocyanates, some platinum salts, certain reactive dyes and plicatic acid). This is an important occupational health problem because […]
The aim of the study was to evaluate existing biomarkers of exposure to xenobiotics and analytical methods from the point of view of the possibility of practical use for assessing and managing occupational and environmental health risk. The study encompassed […]
The result of this study shows that a vast pool of data is available from the many kinds of measurement surveys that have been carried out using 3D body scanner technology. However, to evaluate the data or to derive the […]
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