The science of biomarkers and measurement of exposures via biomarkers has progressed substantially in the past ten years, resulting in several occupational exposure limits being set on the basis of biomarker measurement, and the acceptance of biomarkers as measurement of […]
The study investigated whether leiomyomas in grey seals, collected during the period of decreased levels of organo-chlorines, were in a regressive phase; and whether the period of increased levels of organo-chlorines caused the leiomyomas to proliferate. In addition, in vitro […]
Evaluate the published information on the reproductive endocrinology of aquatic invertebrates with a view to evaluate their potential use in aquatic hazard identification of endocrine modulators.
The result of this study shows that a vast pool of data is available from the many kinds of measurement surveys that have been carried out using 3D body scanner technology. However, to evaluate the data or to derive the […]
The project will provide information on effective in vitro (T-screen & Keratonisation Assay) and in vivo assays (metamorphosis, migration and prolonged FETAX-assay) for alterations of thyroid and retinoid dependent processes. It will bridge the gap between the in vitro and […]
Conduct a literature review on present understanding of sex determination mechanisms in wildlife and the current use of markers of genetic sex for wildlife species selected for use in the testing and evaluation of effects of endocrine modulators. This knowledge […]
This project will examine the ways in which chemicals that cause cancer and genetic damage interact with structural elements in human cells known as cytoskeletal proteins. Because proteins play a key role in cell division, interfering with their functioning can […]
The aim of the study was to evaluate existing biomarkers of exposure to xenobiotics and analytical methods from the point of view of the possibility of practical use for assessing and managing occupational and environmental health risk. The study encompassed […]
The effects of so-called ”endocrine disruptors” (EDs), i.e. hormone-like acting substances of natural or anthropogenic origin or compounds disturbing the endocrine system by other mechanisms, on reproduction are subject to extensive discussion worldwide. For better identification of such effects, regulatory […]
Concerns that toxicological test guidelines may not optimally detect effects on the endocrine system have lead to proposals to enhance the current sub-acute rodent OECD Test Guideline No. 407 (OECD 1995). The efficacy of the modified enhanced (phase 2) protocol […]
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