Skin cancers are very common in humans - with around one million cases/year in the US - and their development can be affected by stimulators of growth such as certain chemicals. Although initiation is clearly extremely important, clonal expansion (promotion) […]
Many environmental chemicals which have been shown to cause cancer in rodents have been implicated in human cancer. However, establishing cause and effect in humans is often impossible. Today, the only accepted test for human carcinogenicity is the two-year rodent […]
Highly reactive carbonyl compounds, aldehydes and ketones - found in a diverse range of natural and synthetic compounds - can cause cancer by damaging cell proteins and DNA. To help prevent this cells contain enzymes, which can break down these […]
About one-half of chemicals tested for long-term health effects in laboratory rats and mice have been found to cause cancer. The accuracy of these tests in predicting human cancer risks needs to be fully understood, particularly for chemicals produced and […]
This project will examine the ways in which chemicals that cause cancer and genetic damage interact with structural elements in human cells known as cytoskeletal proteins. Because proteins play a key role in cell division, interfering with their functioning can […]
The risk assessment of substances to the marine environment is linked with uncertainty due to several reasons, e.g. the marine environment encompasses a higher biodiversity than the freshwater environment. Moreover, the number of toxicity data on marine organisms for the […]
The aim of the study was to study neuro-endocrine regulation, particularly the brain-pituitary-gonad (BPG) axis, 3 freshwater fish species (catfish, trout and tilapia) exposed to 4-nonyl phenol (4-NP) or oestradiol (EE). The research also sought to establish an immortalised gonadotroph […]
The objective of the project is to verify whether impairment of expression and/or function of the gap junctional connexins (elements of the gap junction structure; this structure facilitates "communication" between cells) could be implicated in human male reproductive disorders. An […]
The objective of the project is to develop an in vitro assay for androgenic activity based on the use of prostate cell lines. This involves testing and validation of the cell line LNCaP, which is sensitive to weak androgens, anti-androgens, […]
The objective of the study was to investigate if alkylphenols, which had been shown to bind to oestrogen receptors, might also influence the catabolism and bioavailablity of natural oestrogens by acting as substrates and/or inhibitors of phenolsulphotransferase activity. The results […]
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