The science of biomarkers and measurement of exposures via biomarkers has progressed substantially in the past ten years, resulting in several occupational exposure limits being set on the basis of biomarker measurement, and the acceptance of biomarkers as measurement of […]
The objective of this project was to provide a concise and impartial view of the major developments in academic, institutional and industrial laboratories in Europe, USA and elsewhere working on biomarkers for monitoring human exposure to chemicals. The research into […]
European exposure factor data have been collected in one centrally available, freely accessible site on the Internet: the ExpoFacts database. The process of compiling the database required locating the exposure factor data and evaluating its general applicability and public availability. […]
Di-isocyanates are in many countries a major cause of occupational asthma. However, few recent studies are available in which exposure to isocyanates has been measured and related to respiratory disease risk. Thus, information about exposure response relationships is extremely limited. […]
Exposure assessment plays a key role in the risk assessment procedure. In order to quantify the associated risk and health impact of a possible pollutant, it is necessary to obtain a description of the full-range of exposure distribution. This project […]
Substantial research has been underway for many years on the health effects of pollutants in domestic and commercial buildings. This project has developed a searchable database (termed IERIE) of recent, current and planned indoor environment research activities across Europe. Existing […]
DNA adducts are biomarkers of genotoxicity, and there is an ongoing discussion whether the dose response for DNA-adduct levels also predicts the dose response for mutation or even cancer. A linear low dose-effect relationship is plausible for the rate of […]
The common current assumption is that there is an essentially linear relationship between exposure to genotoxic chemicals, DNA lesion formation and the induction of mutagenic changes. A number of studies of DNA adduct induction indicate that such a linear relationship […]
Specific DNA adducts have been shown to cause gene mutations and carcinogenesis but despite extensive work the biological significance of DNA adduct levels in human populations is largely unknown, in part because all human tissues contain DNA adducts of varying […]
Naturally-occurring and man-made chemicals are widespread in the environment. Predictions of human health risks are usually based on laboratory tests on animals such as rats and mice. Occasionally, cancer does occur in mice alone or in both rats and mice […]
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