The overall aim of this study is to develop quantitative structure-activity relationships relating to biodegradation, biotransformation and bioaccumulation in organisms from different taxa and trophic levels and to develop relationships between biotransformation in microbial systems, invertebrates and vertebrate species. This […]
The specific objectives of this project are to support incorporation of in vitro metabolism data into BCF prediction models and to extrapolate in vitro test results to whole body biotransformation rates (kmet) to be used to refine BCF model predictions. […]
The objectives of these project are: - to gain a quantitative understanding of how chemical and environmental characteristics interact to control long-term time trends of POP/PBT-like substances in various environmental compartments. - to test the ability of current dynamic multimedia models to […]
Under REACH, the new chemicals policy in Europe, exposure scenarios form an essential basis for chemical risk assessment reports to show that chemicals can be used safely. This requires a tiered exposure assessment approach in which the first Tier is […]
Under REACH, the new chemicals policy in Europe, exposure scenarios form an essential basis for chemical risk assessment reports to show that chemicals can be used safely. This requires a tiered exposure assessment approach in which the first Tier is […]
Objectives Overview Identify the key properties and parameters impacting bioconcentration factor (BCF) measurements in the laboratory and those impacting field bioaccumulation factor (BAF) assessments. Select a test set of chemicals which include high production volume (HPV) substances in the […]
The overall objective of this research project is: - To describe the nature of accidental misuse of chemicals and chemical products available to consumers and to put this information in the context of overall estimates of accidental injury from chemicals. […]
The objectives of this project are the further development of strategies making use of the integration of different areas of knowledge on the chemistry and the biological activity of compounds, and their use in the interpretation of biomonitoring data. These […]
The scientific objectives of this project are: 1.To create a tiered screening system for identifying potential PBTs and POPs amongst existing chemicals; 2.To verify whether the potential PBTs / POPs identified in the screening program are present in the European background […]
Current determinations of the exposures that correspond with biomonitoring data (parent/metabolite in blood/urine) are generally conducted with chemical-specific pharmacokinetic models that are physiologically-based (PBPK), to best simulate xenobiotic disposition in complex mammalian systems. While these models are necessary to accurately […]
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