Cefic-lri Programme | European Chemical Industry Council

Complex environments

N5-FRAU: Histopathology of rats exposed to Barium sulfate nanoparticles by life-time inhalation exposure – Effects and Biokinetics

A lot of data are known regarding acute and subacute toxicity of nanomaterials, whereas the long term outcome of inhalation exposure to nanomaterials is still unclear. Long-term inhalation exposure data are only available for nano-TiO2 and Carbon black particles at […]

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ECO30-ARC: Expanding the applicability domain of the chemical activity approach for hazard and risk assessment

The general objectives of this proposed research are (a) to link the toxicity of chemicals to their chemical activity, (b) to expand and critically evaluate the applicability domain of chemical activity for interpreting toxicity data, and (c) to facilitate the […]

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ECO29-UVA: Application of chemostat systems to include adaptation of microbial communities in persistency testing (CHEMADAPT)

Persistence in the environment is a key property in assessing the environmental risks of organic chemicals. Currently, persistence is most often determined using screening tests such as the OECD ready biodegradability tests and sometimes with simulation tests designed to model […]

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ECO27-USHE: Chemicals: Assessment of Risks to Ecosystem Services (CARES)

Aim: To facilitate engagement of the chemical industry, academia and regulators to help develop and evaluate the ecosystem service approach in guiding risk assessment schemes for any type of xenobiotic chemical. Objectives: Review and evaluate state of knowledge and available […]

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ECO8.3-NC3Rs-EAWAG: Round-robin test of the RTgill-W1 cell line assay to study its robustness in establishment and inter-laboratory comparability

To accomplish international recognition of the RTgill-W1 cell line assay for predicting acute toxicity to fish, the project aims to initiate a round-robin trial in order to test the robustness of the established methodology. In particular, the team aims to evaluate the […]

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LRI AWARD 2010: In Quest of new fingerprints of exposure to VOC from consumer products

Volatile organic compounds (VOCs) are ubiquitous in indoor air and their origin is a plethora of various emission sources including building related materials, furniture, equipment and consumer and household related products. Currently, there is international recognition of the contribution of […]

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LRI AWARD 2013: Environmental programming of respiratory allergy in childhood: the applicability of saliva to study the effect of environmental exposures on DNA methylation

Environmental exposures during fetal and early life may contribute to complex disease later in life such as allergic diseases (AD), neurodegenerative diseases and cancer. The underlying mechanisms are still undiscovered, but changes in the epigenetic regulation of gene expression (such […]

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Q3-UMA: Sound Science: Selective citation in science based decision-making

The European Chemical Industry Council has provided funding to Maastricht University for a research project on Research Integrity by exploring one of the most suspected contributors to questionable research practices: selective citation. It is generally accepted that scientific papers should […]

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C3-ED: A comprehensive Epigenomic profile of liver tissue from Rat and Mouse

This project will apply a comprehensive strategy to characterise and curate genome wide methylomes in liver tissues from rats and mouse. This will involve correlation of the profiles generated with public data sets for RNA expression (transcriptomics) and histone modification profiles […]

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AIMT4-UM: DECO2: Moving from DECO towards OECD

The aim of this project is to establish a framework for tools usable in integrated approaches. For this, efforts in our previous DECO project (CEFIC-LRI AIMT3 grant) will be advanced. DECO focused on the prediction of in vivo repeated dose […]

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