Cefic-lri Programme | European Chemical Industry Council

Complex environments

EMSG27: Environmental Effects on Uterine Tissues of Baltic Seals With Special Emphasis on Organochlorines and Uterine Leiomyomas

The study investigated whether leiomyomas in grey seals, collected during the period of decreased levels of organo-chlorines, were in a regressive phase; and whether the period of increased levels of organo-chlorines caused the leiomyomas to proliferate. In addition, in vitro […]

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EMSG31: Aquatic Invertebrates Study – Aquatic Toxicity Project C

Evaluate the published information on the reproductive endocrinology of aquatic invertebrates with a view to evaluate their potential use in aquatic hazard identification of endocrine modulators.

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C1.6: Possibilities and capabilities of 3D-body-scanning systems for the purpose of risk assessment.

The result of this study shows that a vast pool of data is available from the many kinds of measurement surveys that have been carried out using 3D body scanner technology. However, to evaluate the data or to derive the […]

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EMSG28: Development, Validation and Application of in Vitro and in Vivo Test Systems for Non-Oestrogenic Endocrine Disrupting Chemicals in Wildlife

The project will provide information on effective in vitro (T-screen & Keratonisation Assay) and in vivo assays (metamorphosis, migration and prolonged FETAX-assay) for alterations of thyroid and retinoid dependent processes. It will bridge the gap between the in vitro and […]

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EMSG13: Genetic Sex Determination of Fish – Aquatic Toxicity Project D

Conduct a literature review on present understanding of sex determination mechanisms in wildlife and the current use of markers of genetic sex for wildlife species selected for use in the testing and evaluation of effects of endocrine modulators. This knowledge […]

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CC1-FOAR: Development of Criteria for Threshold Genotoxins: Interactions of Chemical Carcinogens With Cytoskeletal Macromolecules

This project will examine the ways in which chemicals that cause cancer and genetic damage interact with structural elements in human cells known as cytoskeletal proteins. Because proteins play a key role in cell division, interfering with their functioning can […]

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D1.1-NOFE: Biomarkers of Exposure – Trends and Key Developments

The aim of the study was to evaluate existing biomarkers of exposure to xenobiotics and analytical methods from the point of view of the possibility of practical use for assessing and managing occupational and environmental health risk. The study encompassed […]

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EMSG36: Further Development and Scientific Evaluation of Appropriate Methods for Identification and Characterisation of Toxic Effects of Hormonally Active Substances on Reproduction in Birds as Part of Multi-Generation-Studies

The effects of so-called ”endocrine disruptors” (EDs), i.e. hormone-like acting substances of natural or anthropogenic origin or compounds disturbing the endocrine system by other mechanisms, on reproduction are subject to extensive discussion worldwide. For better identification of such effects, regulatory […]

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EMSG35-BASF: Enhanced OECD TG 407 – Development and Validation

Concerns that toxicological test guidelines may not optimally detect effects on the endocrine system have lead to proposals to enhance the current sub-acute rodent OECD Test Guideline No. 407 (OECD 1995). The efficacy of the modified enhanced (phase 2) protocol […]

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CC1-UNEW/ZENE: Molecular Toxicology and Structure Activity Relationships in the Rodent Carcinogenesis of Industrially Important Dienes and the Relevance for Human Cancer

About one-half of chemicals tested for long-term health effects in laboratory rats and mice have been found to cause cancer. The accuracy of these tests in predicting human cancer risks needs to be fully understood, particularly for chemicals produced and […]

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