Cefic-lri Programme | European Chemical Industry Council

Complex environments

EMSG16: Epidemiological Studies of Endocrine Disruptors and Human Health

Hypospadias is a male birth defect in which the urethral orifice is abnormally located on the ventral side of the penis. In western countries, the prevalence of hypospadias varies from 2 to 8 cases per 1000 live births. An increase […]

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CC2-001-FSBW: Evaluation of Chemically-Induced Genotoxicity as an Increment to Background DNA Damage and Spontaneous Mutagenesis

DNA adducts are biomarkers of genotoxicity, and there is an ongoing discussion whether the dose response for DNA-adduct levels also predicts the dose response for mutation or even cancer. A linear low dose-effect relationship is plausible for the rate of […]

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IRTA2-002-UUIR: Heterogeneity in Response to Iso-Cyanate Exposure in the Work Environment

Di-isocyanates are in many countries a major cause of occupational asthma. However, few recent studies are available in which exposure to isocyanates has been measured and related to respiratory disease risk. Thus, information about exposure response relationships is extremely limited. […]

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EMSG17: Identification of Biomedical Endpoints of Oestrogen Action in the Male Rat With Possible Confirmation in Primate Model and in Man

The objective of the project was to identify biochemical endpoints of oestrogen action in the male rat during foetal and neonatal development, which may have potential for monitoring the level of "oestrogen" exposure of individual animals, either in infancy or […]

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A3.1: Establishment and Management of a Research Inventory on the Indoor Environment (IERIE)

Substantial research has been underway for many years on the health effects of pollutants in domestic and commercial buildings. This project has developed a searchable database (termed IERIE) of recent, current and planned indoor environment research activities across Europe. Existing […]

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B3.1-CUSS: Strategies for Success? Managing Chemical Risks in Small Workplaces: a Review of European Practice

The research project is essentially a review of literature and informed interest on the main factors that determine effective and sustainable risk management in the use of chemical substances in small enterprises and an exploration of the supports for their […]

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EMSG19: Chemicals and Pregnancy Study-UK (CHAPS-UK): Multicentre Study of Occupational Exposure to Chemicals and Male Fertility

The research institutes will study 6000 men attending any of the 10 fertility clinics in the UK over a period of 2 years. They will be classified as either fertile or infertile on the basis of sperm parameters. Standardised methods […]

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A3.3: The EXPOLIS-Index Study, Human Exposure Patterns for Health Risk Assessment:Indoor Determinants of Personal Exposures in the European Expolis Population in Athens, Basel, Grenoble, Milan, Helsinki, Oxford And Praha

Exposure assessment plays a key role in the risk assessment procedure. In order to quantify the associated risk and health impact of a possible pollutant, it is necessary to obtain a description of the full-range of exposure distribution. This project […]

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ECO3A-TUHH: MarSens – How Should We Deal with the Uncertainty in the Extrapolation of the Sensitivity of Marine Organisms to Narcotics? Critical Review of the State of the Art of Marine Risk Assessment and Recommendations for Future Research

The risk assessment of substances to the marine environment is linked with uncertainty due to several reasons, e.g. the marine environment encompasses a higher biodiversity than the freshwater environment. Moreover, the number of toxicity data on marine organisms for the […]

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EMSG20: Environmental Factors and Male Reproductive Functions. A Cohort Study of the Incidence of Cryptorchidism and Hypospadia in 5000 Newborn Boys in the Rotterdam Area

This is a study of 10,000 men, their (pregnant) partners and their new-born children. Information will be collected on the incidence of urogenital disorders such as Cryptorchidism, Hypospadia, lifestyle, working conditions of the male partner and time to pregnancy. The […]

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