Cefic-lri Programme | European Chemical Industry Council

Complex environments

EMSG36: Further Development and Scientific Evaluation of Appropriate Methods for Identification and Characterisation of Toxic Effects of Hormonally Active Substances on Reproduction in Birds as Part of Multi-Generation-Studies

The effects of so-called ”endocrine disruptors” (EDs), i.e. hormone-like acting substances of natural or anthropogenic origin or compounds disturbing the endocrine system by other mechanisms, on reproduction are subject to extensive discussion worldwide. For better identification of such effects, regulatory […]

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EMSG24: Environmental Oestrogens and the Neuro-Endocrine Regulation of Reproduction of Fish

The aim of the study was to study neuro-endocrine regulation, particularly the brain-pituitary-gonad (BPG) axis, 3 freshwater fish species (catfish, trout and tilapia) exposed to 4-nonyl phenol (4-NP) or oestradiol (EE). The research also sought to establish an immortalised gonadotroph […]

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CC2-001-UWSW: Dose Relationships of DNA Adducts and Mutations

The common current assumption is that there is an essentially linear relationship between exposure to genotoxic chemicals, DNA lesion formation and the induction of mutagenic changes. A number of studies of DNA adduct induction indicate that such a linear relationship […]

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IRTA2-001-TNOV: Characterisation of Respiratory Tract Sensitization to Improve Hazard Identification of Respiratory Allergens

This project aimed to improve hazard identification of respiratory chemical allergens, as is presently being done by measuring proliferation and cytokine production in local lymph nodes and IgE in serum upon dermal application of the chemical in question. To this […]

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EMSG29: Examination of Bull Sperm as a Sentinel Species for Male Reproductive Health

Discussions over possible declines in male sperm counts are hampered by the lack of human data. Data is readily available, however, on sperm counts from other mammals, and this can provide helpful insight to questions regarding male fertility rates. This […]

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EMSG31: Aquatic Invertebrates Study – Aquatic Toxicity Project C

Evaluate the published information on the reproductive endocrinology of aquatic invertebrates with a view to evaluate their potential use in aquatic hazard identification of endocrine modulators.

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CC2-001-FSBW: Evaluation of Chemically-Induced Genotoxicity as an Increment to Background DNA Damage and Spontaneous Mutagenesis

DNA adducts are biomarkers of genotoxicity, and there is an ongoing discussion whether the dose response for DNA-adduct levels also predicts the dose response for mutation or even cancer. A linear low dose-effect relationship is plausible for the rate of […]

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IRTA2-001-VITO: In Vivo and In Vitro Characterisation of Chemical Respiratory Allergens: Development of an In Vitro Assay Using Gene Expression Profiling

The main objective of this project is the development of an approach/strategy that can be used to identify chemical allergens and if possible to discern respiratory from contact sensitizers. In order to accomplish this, the proposed study aims to identify […]

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EMSG8: Are Connexins, the Gap Junctional Integral Proteins, Involved in Male Reproductive Disorders Associated With Possible Exposure to Endocrine Disrupting Agents?

The objective of the project is to verify whether impairment of expression and/or function of the gap junctional connexins (elements of the gap junction structure; this structure facilitates "communication" between cells) could be implicated in human male reproductive disorders. An […]

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EMSG13: Genetic Sex Determination of Fish – Aquatic Toxicity Project D

Conduct a literature review on present understanding of sex determination mechanisms in wildlife and the current use of markers of genetic sex for wildlife species selected for use in the testing and evaluation of effects of endocrine modulators. This knowledge […]

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