Intelligent testing
S3-UCRAIN: Development of a robust participatory regulatory framework to enhance the wider acceptance of innovative chemical technologies
This project is looking to identify the type and form of policy evidence required by policy makers to operationalize benefit-risk approaches to technology innovation. The project's objectives are to: 1. Map current gaps in existing approaches to developing scientific evidence […]
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ECO23-VUAM: Time-Integrative Passive sampling combined with Toxicity Profiling (TIPTOP): an effect-based strategy for cost-effective chemical water quality assessment
The TIPTOP study will test the following two hypotheses: Compound-by-compound chemical water quality assessment based on concentrations of target-analyzed pollutants is toxicologically and ecologically less relevant and thereby less protective than risk assessment based on bioassay responses to the complex […]
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B12-ETHZ: Assessing the relevance of the dust contribution in consumer exposure to substances from consumer products and articles (DustEx)
This project investigates the importance of house dust as a source of human exposure to substances in consumer products and articles. The project will explore the dust pathway in relation to the direct pathways and develop a decision tree as well as […]
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B13-UCIN: Development of a mechanistic in silico multi-scale framework to assess dermal absorption of chemicals
The research project will build upon existing technology for estimating dermal penetration of chemicals by addressing unmet needs in a mechanistically-based manner that will not only provide an improved risk assessment tool for the immediate future but also enrich the […]
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B11-CERTH: Integrated External and Internal Exposure Modelling Platform (INTEGRA)
The objective of INTEGRA is to bring together all available information within a coherent methodological framework for assessing the source-to-dose continuum for the entire life cycle of substances covering an extensive chemical space. Hence, the major component of INTEGRA will […]
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ECO20-UA: Development of an alternative testing strategy for the fish early life-stage test for predicting chronic toxicity
The main objective of this project is to use a mechanistic framework to develop and propose a high-throughput tiered-testing strategy for screening and prioritizing chemicals for FELS testing (OECD 210). The main objective can be divided into four parts: Establish […]
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ECO21-ARC: Improving the performance and expanding the applicability of a mechanistic bioconcentration model for ionogenic organic compounds (IOCs) in fish (BIONIC)
The general objective of this proposed research is to improve the mechanistic understanding of bioaccumulation of ionogenic organic chemicals (IOCs) in aquatic organisms, primarily fish, in the form of mass balance models and to increase the confidence of applying these […]
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B10-ICL: Animal and human NOAELS: cross-species comparison, inference and synthesis
The overall aim of the proposed project is to provide a systematic and quantifiable comparison of NOAELs derived from animal studies with those from human studies for a range of chemicals and to develop robust evidence synthesis (meta-analytical) methodology combining […]
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B9-VITO: DRESS – DeRmal Exposure aSsessment Strategies
The use of chemicals in consumer products has been, and still is, of great societal importance. Their use allowed industry to achieve a high level of innovation, as well as greatly improve the quality of day-to-day life of many consumers. […]
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HBM4-VITO:Understanding inter- and intra-individual variability in HBM spot samples
In many large-scale human biomonitoring (HBM) surveys, single samples of blood, urine or other bodily matrices are collected from large numbers of individuals recruited from the general population. These HBM surveys aim to obtain information on the distribution of exposures […]
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