This project is looking to identify the type and form of policy evidence required by policy makers to operationalize benefit-risk approaches to technology innovation. The project's objectives are to: 1. Map current gaps in existing approaches to developing scientific evidence […]
The TIPTOP study will test the following two hypotheses: Compound-by-compound chemical water quality assessment based on concentrations of target-analyzed pollutants is toxicologically and ecologically less relevant and thereby less protective than risk assessment based on bioassay responses to the complex […]
This project investigates the importance of house dust as a source of human exposure to substances in consumer products and articles. The project will explore the dust pathway in relation to the direct pathways and develop a decision tree as well as […]
The research project will build upon existing technology for estimating dermal penetration of chemicals by addressing unmet needs in a mechanistically-based manner that will not only provide an improved risk assessment tool for the immediate future but also enrich the […]
The objective of INTEGRA is to bring together all available information within a coherent methodological framework for assessing the source-to-dose continuum for the entire life cycle of substances covering an extensive chemical space. Hence, the major component of INTEGRA will […]
The main objective of this project is to use a mechanistic framework to develop and propose a high-throughput tiered-testing strategy for screening and prioritizing chemicals for FELS testing (OECD 210). The main objective can be divided into four parts: Establish […]
The general objective of this proposed research is to improve the mechanistic understanding of bioaccumulation of ionogenic organic chemicals (IOCs) in aquatic organisms, primarily fish, in the form of mass balance models and to increase the confidence of applying these […]
The overall aim of the proposed project is to provide a systematic and quantifiable comparison of NOAELs derived from animal studies with those from human studies for a range of chemicals and to develop robust evidence synthesis (meta-analytical) methodology combining […]
The use of chemicals in consumer products has been, and still is, of great societal importance. Their use allowed industry to achieve a high level of innovation, as well as greatly improve the quality of day-to-day life of many consumers. […]
In many large-scale human biomonitoring (HBM) surveys, single samples of blood, urine or other bodily matrices are collected from large numbers of individuals recruited from the general population. These HBM surveys aim to obtain information on the distribution of exposures […]
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