Nanotechnology is a new and fast emerging field that involves manufacture of materials that are less than 100 nm in size in one dimension. Due to their extremely small size, engineered nanoparticles (ENPs) exhibit properties that are vastly different from […]
The objectives of this project are: - to test the suitability of existing OECD testing guidelines for nanoscaled amorphous silicon dioxide (NASD) and ZnO; - to subject these test materials to OECD guideline testing; - to supplement these guidelines with […]
The specific objectives of this project are as follows: - to provide genome-wide maps of kinetic changes in gene expression induced in draining lymph nodes following exposure of mice to a panel of selected chemicals (comprising chemicals known to cause […]
Exposure to indoor air contaminants is one of the major sources of exposure to environmental health stressors, especially given that people spend the majority of their time indoors. Indoor air quality is determined by the ability of outdoor source pollutants […]
Exposure to chemical agents originates either from environmental contamination (air, water), or from consumer products (food contact materials, construction materials, cosmetics, clothes, etc.) through multiple routes, namely inhalation, ingestion and dermal contact. Aggregate exposure, i.e. the quantitative exposure assessment to […]
The overall goal of this project is to recommend a scientifically sound and defensible minimalized experimental design for fish bioconcentration measurement. This experimental design will meet the "spirit" of the OECD 305 protocol producing key regulatory data, but ideally will […]
The general objective of the research project is to generate greater confidence and acceptance for the application of CBBs in the scientific community and in regulatory contexts. A key element of this research will be to compare model predictions that provide mechanistic […]
Chemical bioaccumulation is an interesting scientific phenomenon and an important regulatory consideration. The production and use of chemicals that are assessed as having a high potential to accumulate can be restricted in many jurisdictions. At the same time, recent scientific […]
There is a large body of literature published in peer-reviewed journals that report risk factors for breast cancer. Whilst studies continue to be reported that provide further evidence of an association between breast cancer incidence and established causal agents related […]
The ADEPT software is a quick assessment tool to calculate European concentrations and deposition of airborne chemical contaminants. In a tiered approach to risk assessment this could be the second or even first tier level. The model gives the result […]
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