The general objective of this proposed research is to improve the mechanistic understanding of bioaccumulation of ionogenic organic chemicals (IOCs) in aquatic organisms, primarily fish, in the form of mass balance models and to increase the confidence of applying these […]
This project will support the acceptance of the Cefic MIAT Decision Tree by identifying appropriate monitoring studies of chemicals in the EU and applying the Decision Tree to the data generated by the studies. The goal of this project is […]
The objective of this project is to estimate the relative proportions of the real life exposures to residential indoor air contaminant mixtures in Europe which are (i) of low health concern (ii) of health concern because of the effects of […]
The overall aim of the proposed project is to provide a systematic and quantifiable comparison of NOAELs derived from animal studies with those from human studies for a range of chemicals and to develop robust evidence synthesis (meta-analytical) methodology combining […]
The first objective of this project is to develop a transparent framework that improves the prediction of the repeated dose toxicity of new chemicals by integrating chemoinformatic data with biological information from'omics' and HTS technologies. To create this framework, it […]
In many large-scale human biomonitoring (HBM) surveys, single samples of blood, urine or other bodily matrices are collected from large numbers of individuals recruited from the general population. These HBM surveys aim to obtain information on the distribution of exposures […]
The use of chemicals in consumer products has been, and still is, of great societal importance. Their use allowed industry to achieve a high level of innovation, as well as greatly improve the quality of day-to-day life of many consumers. […]
In this project, we intend to investigate two hypotheses that should (i) help better understand the value and information content of the existing OECD 308 protocol, and (ii) help develop an improved test strategy for assessing persistence in sediment and […]
Considering the available definitions of endocrine disrupting compounds (Weybridge, 1996 and WHO/IPCS, 2002) it is recommended to follow an appropriate experimental design, duration of exposure, and completeness of relevant endpoints (OECD, 2002). As expected human exposures to chemicals, pesticides, biocides, […]
The overall goal of this project is to characterize the potential in vitro and in vivo activities of plant-derived endocrine active compounds (EACs) versus synthetic substances and to evaluate potential combinatory effects of relevance to fish reproductive health. In particular, the […]
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