The overall objective of the project is to determine whether model organisms with genetically sensitized signal transduction pathways can be used as predictors of mammalian developmental toxicity. Specific objectives: - Evaluate the effect of model developmental toxicants on the morphological […]
With published research suggesting growing numbers of children affected by an array of neurodevelopmental disorders, questions regarding etiology will continue to be raised. The uses of neurodevelopmental tests in studies of environmental chemicals and pediatric neurodevelopmental disorders have been reviewed […]
The objectives of this project are the further development of strategies making use of the integration of different areas of knowledge on the chemistry and the biological activity of compounds, and their use in the interpretation of biomonitoring data. These […]
The aim of this project is to characterize adult rat testicular toxicity induced by compounds that have either an estrogenic or a non-estrogenic mode of action. To fully realise this goal, the differentiation between normal background variability (ie no effect), […]
The scientific objectives of this project are: 1.To create a tiered screening system for identifying potential PBTs and POPs amongst existing chemicals; 2.To verify whether the potential PBTs / POPs identified in the screening program are present in the European background […]
Biomonitoring is a useful tool to aid the assessment of exposure to many chemical substances but currently our ability to detect hazardous substances (or their metabolites and effects) may often exceed our understanding of the biological relevance of these results. […]
Current determinations of the exposures that correspond with biomonitoring data (parent/metabolite in blood/urine) are generally conducted with chemical-specific pharmacokinetic models that are physiologically-based (PBPK), to best simulate xenobiotic disposition in complex mammalian systems. While these models are necessary to accurately […]
Objective: Development of a tiered tool with compartmental and physiologically based toxicokinetic models, taken up in a software program, to derive Biomonitoring Equivalent Guidance Values (BEGV) based on existing health based acceptable daily doses or acceptable health based daily exposures. […]
Many new technologies' introductions have been hindered by societal negativity regarding their development, application and commercialisation. Whilst considerable research activity has been directed towards understanding the underlying determinants of societal acceptance emerging technologies, this has been done on a case […]
The objective of the project is to provide a review of population models which can be directly used or which might be modified for the ecological risk assessment of chemicals (ERA). The main focus will be on the aquatic environment […]
Terms and Conditions of Use | Privacy Policy | Cookie Policy | Coockie Settings
© Copyright 2017 Cefic | European Chemical Industry Council. All rights reserved.
