Cefic-lri Programme | European Chemical Industry Council

Projects

B3.3: The Intake Fraction (iF) concept: modelling, expansion and application tests

In order to help correlate the exposure of a population to a toxicant directly to the source of exposure, researchers have developed a concept called the intake fraction (iF), which is a dimensionless variable. The estimation of the iF relationship […]

Read more

EMSG42: Increase of the robustness of the fish endocrine assay and avoidance of irrelevant endpoints

The objective of this study was to determine the influence of the test items potassium permanganate, 2-methoxyethanol and octanol to reproduction and the endocrine system of fathead minnow (Pimephales promelas). For this purpose, mature male and female fathead minnow were exposed in […]

Read more

EMSG38: Review of the Relative Contribution of Industrial Chemicals, Compared to Steroids, in Causing the Sexual Disruption in Wild Fish Populations

Steroidal estrogens, originating principally from human excretion, are likely to play a major role in causing widespread endocrine disruption in wild populations of the roach (Rutilus rutilus), a common cyprinid fish, in rivers contaminated by treated sewage effluents. Given the […]

Read more

21DAY: Phase 3 of the validation of the OECD Fish Screening Assay

The eight studies in the attached report were conducted as part of OECD Test Guideline program to validate a standardized OECD protocol for a 21-day fish screening assay for the detection of endocrine active substances (i.e. estrogen, aromatase inhibitors, androgen). […]

Read more

ECO6-CSL: Identifying Transgeneric Biotransformational Potential

When aquatic organisms are exposed to chemicals in the environment, some of these chemicals maybe universally metabolised, whilst others are either metabolised by specific species/taxa or are non-metabolisable and therefore may bioaccumulate. The objective of this work was to develop […]

Read more

D2.2-VITO: Generation and Application of a Model to Determine Intra- and Inter-individual Variation in Biomarkers

Biomarkers which reflect levels of pollutants in the human body offer a unique opportunity to investigate impact of environmental pollution on humans. Biomarker levels in the general population are influenced by genetic, physiological and external factors. Knowledge on which factors […]

Read more

EMSG33: Chemical Repository

OECD Test Guideline Validation: to provide a set of defined test chemicals for the OECD test methods development for endocrine active chemicals and to guarantee that test method validation under OECD leads to reliable results by always using the same […]

Read more

EMSG35-BASF: Enhanced OECD TG 407 – Development and Validation

Concerns that toxicological test guidelines may not optimally detect effects on the endocrine system have lead to proposals to enhance the current sub-acute rodent OECD Test Guideline No. 407 (OECD 1995). The efficacy of the modified enhanced (phase 2) protocol […]

Read more

Cefic-Lri Programme Responsible Care

© Copyright 2017 Cefic | European Chemical Industry Council. All rights reserved | Terms and Conditions of Use