Cefic-lri Programme | European Chemical Industry Council

Projects

A2.1: Literature Survey On Dermal Deposition In The Chemical Industry

Making reliable estimates of the amounts of chemicals deposited on the skin and clothing in the workplace is essential in evaluating any health risks. It also helps in assessing the effectiveness of protective equipment. There is a lack of detailed […]

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A1.3-UNAB: Development Of A Database For Workplace Exposure Measurements

Measurement of human exposure at work forms the cornerstone of risk management strategies. With the advent of powerful computer databases these measurements have been collected in several parts of Europe, by industry, government agencies and others such as universities and […]

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A1.2-UNAB: Database Of European Workplace Exposure Research Activities (HEROX)

Cefic identified a need for an inventory of European research on human workplace exposure to chemicals. Access to this information is needed for setting safe occupational exposure limits and to help quantify economic and health implications of exposures. A database […]

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B3.7-HSL: The Rapid Generation And Analysis of Physiologically-Based Pharmacokinetic Models (PBPK Model)

The widespread use and acceptance of PBPK modelling has been advocated for many years, as this technique offers a more scientific and quantitative approach to chemical risk assessment, as well as offering the opportunity of a marked reduction in the […]

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B2.3-IOM: Variability and Uncertainty in Chemical Exposures for Regulatory Risk Assessment

The aim of this project is to investigate how the variability and uncertainty of occupational inhalation exposure information may be better incorporated into the European regulatory risk assessment process. In this proposal, we have chosen to focus specifically on inhalation […]

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B2.2-FoBiG: Provide Examples Where Risk Characterisations can be Conducted With the Existing and Possible Inadequate Data Sets

This project will evaluate the estimates used today by several organisations (e.g. U.S.-EPA, WHO, EU) to assess the human health risks of chemical exposure, which result in the derivation of human limit values such as acceptable daily intake, reference doses […]

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B2.1-TNO: Characterisation of Uncertainty and Variation in Assessment of Chronic Occupational Exposure

Many adverse health effects of chemical exposure occur after repeated contact over long periods. In assessing the risks of such chronic effects in the workplace, "reasonable worst case" estimates of exposure during a shift or working day are often used. […]

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B1.1-FRAU: Identification of Structure Activity Relationships Alerts for Substances With Low NOELs (REPDOSE)

The toxicological data profiles of many of the more than 100,000 substances included in the EINECS are incomplete. Scientific tools are needed to minimize test requirements and to prioritise research needs. Here consideration of Structure Activity Relationships (SAR) could be […]

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IRTA2-001-HSL: Development of a Human In Vitro Testing Model to Distinguish Immune Responses to Chemical Respiratory vs Contact Allergens

The main objective of this project is to use dendritic-like cells derived from a human cell line to develop a robust in vitro system to distinguish between respiratory vs contact sensitising chemicals. Whilst the use of cell lines will help […]

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IRTA2-001-VITO: In Vivo and In Vitro Characterisation of Chemical Respiratory Allergens: Development of an In Vitro Assay Using Gene Expression Profiling

The main objective of this project is the development of an approach/strategy that can be used to identify chemical allergens and if possible to discern respiratory from contact sensitizers. In order to accomplish this, the proposed study aims to identify […]

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