Cefic-lri Programme | European Chemical Industry Council

Projects

B3.7-HSL: The Rapid Generation And Analysis of Physiologically-Based Pharmacokinetic Models (PBPK Model)

The widespread use and acceptance of PBPK modelling has been advocated for many years, as this technique offers a more scientific and quantitative approach to chemical risk assessment, as well as offering the opportunity of a marked reduction in the […]

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B2.3-IOM: Variability and Uncertainty in Chemical Exposures for Regulatory Risk Assessment

The aim of this project is to investigate how the variability and uncertainty of occupational inhalation exposure information may be better incorporated into the European regulatory risk assessment process. In this proposal, we have chosen to focus specifically on inhalation […]

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B2.2-FoBiG: Provide Examples Where Risk Characterisations can be Conducted With the Existing and Possible Inadequate Data Sets

This project will evaluate the estimates used today by several organisations (e.g. U.S.-EPA, WHO, EU) to assess the human health risks of chemical exposure, which result in the derivation of human limit values such as acceptable daily intake, reference doses […]

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B2.1-TNO: Characterisation of Uncertainty and Variation in Assessment of Chronic Occupational Exposure

Many adverse health effects of chemical exposure occur after repeated contact over long periods. In assessing the risks of such chronic effects in the workplace, "reasonable worst case" estimates of exposure during a shift or working day are often used. […]

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B1.1-FRAU: Identification of Structure Activity Relationships Alerts for Substances With Low NOELs (REPDOSE)

The toxicological data profiles of many of the more than 100,000 substances included in the EINECS are incomplete. Scientific tools are needed to minimize test requirements and to prioritise research needs. Here consideration of Structure Activity Relationships (SAR) could be […]

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IRTA2-001-HSL: Development of a Human In Vitro Testing Model to Distinguish Immune Responses to Chemical Respiratory vs Contact Allergens

The main objective of this project is to use dendritic-like cells derived from a human cell line to develop a robust in vitro system to distinguish between respiratory vs contact sensitising chemicals. Whilst the use of cell lines will help […]

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IRTA2-001-VITO: In Vivo and In Vitro Characterisation of Chemical Respiratory Allergens: Development of an In Vitro Assay Using Gene Expression Profiling

The main objective of this project is the development of an approach/strategy that can be used to identify chemical allergens and if possible to discern respiratory from contact sensitizers. In order to accomplish this, the proposed study aims to identify […]

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IRTA2-001-TNOV: Characterisation of Respiratory Tract Sensitization to Improve Hazard Identification of Respiratory Allergens

This project aimed to improve hazard identification of respiratory chemical allergens, as is presently being done by measuring proliferation and cytokine production in local lymph nodes and IgE in serum upon dermal application of the chemical in question. To this […]

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IRTA2-001-SYNG: Transcript Profiling and Cytokine Fingerprinting : Identification and Characterisation of Chemical Respiratory Allergens

Allergic hypersensitivity of the respiratory tract is an important occupational health problem. A major constraint in the development of appropriate methods for the prospective identification of chemical respiratory allergens is the continuing uncertainty regarding the immunobiological mechanisms of this disease […]

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R2-BIHH: The Physiological and Bronchial Inflammatory Marker Response to Exposure in the Workplace in Patients With Occupational Asthma

Occupational asthma is the commonest occupational lung disease, accounting for 5% of all cases of asthma, and incidence is rising. Sufferers lose on average half their total take-home income (including compensation) for four years after diagnosis. Whilst the clinical and […]

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