Intelligent testing
EEM3-UDUR: Terrestrial Runoff Modeling for Risk Assessment of Chemical Exposure (TERRACE)
This project aimed to create an integrated software package to assess the transport of chemical pollutants in the environment. It provided European and national regulatory agencies and industry with a state-of-the-art tool for better prediction of concentrations of chemicals - […]
Read more
CC2-MRCT: Gene Expression Profiling of Skin Carcinogenesis in Mice Using cDNA Microarrays
Skin cancers are very common in humans - with around one million cases/year in the US - and their development can be affected by stimulators of growth such as certain chemicals. Although initiation is clearly extremely important, clonal expansion (promotion) […]
Read more
EEM9-PGEU: Quantitative Structure-Activity Relationships software for data management
The software system will consist of functional modules allowing evaluation of the data stored in a database and various user interface modules. Compounds database will contain chemical structure, identifiers (including CAS numbers), imported descriptors and experimental data. The functional modules […]
Read more
A2.3: International Workshop on Methods to Determine Dermal Permeation for Human Risk Assessment
This Workshop was designed to bring together relevant expertise and to reach a consensus recommendation on a standardised protocol for in vitro determination of permeability coefficients. The proposed protocol is intended, in the first instance, for testing aqueous soluble chemicals […]
Read more
ECO1B-WRCN: Comparison of Marine and Freshwater Data and Test Methods Review of Literature – Phase I
The environmental risk posed by any new chemical produced or used in substantial quantities in the EU had to be assessed. This process involved estimating the concentration of the substance that could be present in water without harming aquatic life. […]
Read more
R2-BIHH: The Physiological and Bronchial Inflammatory Marker Response to Exposure in the Workplace in Patients With Occupational Asthma
Occupational asthma is the commonest occupational lung disease, accounting for 5% of all cases of asthma, and incidence is rising. Sufferers lose on average half their total take-home income (including compensation) for four years after diagnosis. Whilst the clinical and […]
Read more
ECO1C-TUD: Comparison of Soil and Sediment Ecotoxicity Data and Test Methods
Existing data on ecotoxicity of chemicals for water, sediment and soil varies widely in quality, quantity, validity, and how representative it is. This is due to environmental concerns having initially focused water, with soil and sediment taken into account only […]
Read more
B1.1-FRAU: Identification of Structure Activity Relationships Alerts for Substances With Low NOELs (REPDOSE)
The toxicological data profiles of many of the more than 100,000 substances included in the EINECS are incomplete. Scientific tools are needed to minimize test requirements and to prioritise research needs. Here consideration of Structure Activity Relationships (SAR) could be […]
Read more
ECO2A-ASTRA: Understanding and Measurement of Persistence in the Marine and Terrestrial Compartments
The persistence of a chemical in the environment - how resistant it is to being broken down in nature - is hard to predict. Its tendency to build up in living organisms - to bioconcentrate or bioaccumulate - is similarly […]
Read more
B2.1-TNO: Characterisation of Uncertainty and Variation in Assessment of Chronic Occupational Exposure
Many adverse health effects of chemical exposure occur after repeated contact over long periods. In assessing the risks of such chronic effects in the workplace, "reasonable worst case" estimates of exposure during a shift or working day are often used. […]
Read more